Can Ketamine Be Used To Treat Depression?

can ketamine be used to treat depression?

Depression is a common struggle for millions of people. Some only struggle with it for short periods of time: during the loss of a loved one or a medical crisis. Others are forced to battle with depression for their entire lives.

Depression can be debilitating. And some depression is so severe that antidepressants simply don’t make any difference. Treatment-resistant depression can be one of the most discouraging and confusing things to happen to a person.

But, in recent years, scientists have begun to rediscover psychedelic treatment as an option for dealing with major depressive disorder and other mental illnesses.

LSD and DMT are some more well-known psychedelics, but ketamine has had a particularly positive effect on treatment for depression. It has made a strong impact on the medical community in recent years.

So, in an effort to get you all the facts about the innovative treatment technologies out there today, we’re going to walk through ketamine and its uses against depression. Is this form of treatment viable? How does it compare to other depression therapies out there?

Let’s take a look.

what is ketamine?

Ketamine is a psychedelic drug that was discovered in the 1960s. It was originally used as an anesthetic alternative that could relieve pain and induce sleep.

Ketamine is an anesthetic that doesn’t reduce heart rate or slow breathing, so it can be used without putting the patient on a ventilator if necessary. For this reason, it was incredibly influential during the war.

It was introduced into clinical practice in the 70s, but it was soon outlawed due to its widespread recreational use.

For a while, ketamine faded into the background, but scientists have begun to study it again in recent years, particularly regarding the treatment of depression and other mental illnesses. In 2019, ketamine was officially approved by the FDA to help treat resistant depression with a product called esketamine, a nasal spray.

how can ketamine help with depression?

Ketamine has various effects on the brain that work together to have its antidepressant effect.

Ketamine binds to specific receptors in the brain called NMDA receptors. When ketamine locks into them, there is an increase in a neurotransmitter called glutamate. Glutamate, in turn, binds to another type of receptor called AMPA receptors.

So, ketamine blocks NMDA receptors and activates AMPA receptors. This creates a state known as synaptogenesis, which allows your body to help synapses communicate with each other along new neural pathways.

Creating these new pathways allows you to get out of the rut of your depressive pathways, opening your mind to new experiences and worlds of thought.

how is ketamine different from SSRIs?

SSRIs, or selective serotonin reuptake inhibitors, are the most common form of antidepressant. They work by promoting the levels of serotonin in your brain. Ketamine is different.

Ketamine focuses on your neurons, binding to specific receptors to generate certain reactions and inhibit others. Ketamine works to target the source of the problem in your brain: neuron communication.

Depression is characterized by structural alterations in the brain that result in atrophy and loss of neurons in the part of your brain that regulates emotion. Ketamine helps restore the structure of your brain and promotes its ability to create new neurons and new neural pathways.

But the biggest difference is in the effectiveness of SSRIs. Studies show that for 40% of people with depression, SSRIs are simply not adequate. For these people with treatment-resistant depression, ketamine is a viable option that has been shown to consistently help with this type of depression.

how does ketamine treatment work?

There are a few different ways that you can go about ketamine treatment. As we said before, nasal spray is a very common method. However, the nasal spray only contains S-ketamine, which is only a part of the full chemical compound, so its effects could be limited.

Another common method is through IV. Intravenous administration of ketamine works very quickly and causes the most potent psychedelic experiences.

You can also get ketamine via an injection or shot. This shows similar effectiveness to IV ketamine administration.

All of those treatments pose some inconveniences because they all require you to have them administered by a medical professional, so you have to go into a doctor’s office to receive the treatment. Besides, ketamine infusions, especially IV, are all costly and, therefore, not accessible to everybody.

Ketamine can also be administered by mouth. A simple pill can have effects comparable to IV administration, and you can have the treatment done in the comfort of your own home.

what are the side effects of ketamine?

As with any medication or drug, some potential side effects could come with the use of ketamine. Side effects may include changes in blood pressure (would suggest to change drops in blood pressure to changes in blood pressure. We have patients with hypertension monitor their blood pressure during treatment because it can increase it) , nausea, and vomiting, perceptual disturbances (hallucinations), or dissociation (out of body experience).

However, many patients report that if they experience hallucinations or dissociations, it is a pleasant and even eye-opening or freeing experience. So some may not even describe those as adverse side effects.

who can benefit from ketamine treatment?

The fact is that so many people stand to gain from going through psychedelic therapy. Ketamine could potentially change the course of your depression and move you into a healthy life. So here are just a few people who stand to gain a lot from this type of treatment.

older women

Older women can be at a particular disadvantage when it comes to depression.

For starters, older people, in general, are more likely to experience depression. But that changes if you need home healthcare or if you’re hospitalized.

Older people are more likely to have a medical condition that requires extensive treatment, and that can have a very negative impact on your mental health. For people who need this type of care, rates of depression jump from under 5% to between 11.5% and 13.5%.

In addition to that, women have higher depression rates than their male counterparts. About 5.5% of women have major depression, compared to 3.2% of men. And this trend is consistent throughout life. On top of that, the most likely age group to struggle with depression is young girls.

This means that older women are a likely group of people struggling with depression. And as we said before, ketamine is most effective in long-term, major depression cases, so older women might have much to gain from this psychedelic treatment.

veterans

Veterans can benefit from ketamine in more ways than one. It’s well known that veterans are at higher risk for mental disorders such as depression and PTSD.

Well, the good news is that ketamine has shown positive effects on both of these illnesses. We’ve already talked about how effective ketamine is with depression, so let’s look at how it works against PTSD.

Well, one study compared the effectiveness of ketamine compared with midazolam, a standard prescription for PTSD. Results showed that patients given ketamine responded well almost three times more often than patients treated with midazolam.

This indicates that PTSD is a more effective treatment for PTSD than more standard treatments.

people who need immediate improvement

Veterans can benefit from ketamine in more ways than one. It’s well known that veterans are at higher risk for mental disorders such as depression and PTSD.

Well, the good news is that ketamine has shown positive effects on both of these illnesses. We’ve already talked about how effective ketamine is with depression, so let’s look at how it works against PTSD.

Well, one study compared the effectiveness of ketamine compared with midazolam, a standard prescription for PTSD. Results showed that patients given ketamine responded well almost three times more often than patients treated with midazolam.

This indicates that PTSD is a more effective treatment for PTSD than more standard treatments.

people who didn’t benefit from SSRIs

We touched on this earlier, but SSRIs are just not effective for a large number of people. But treatment-resistant depression is what ketamine is best at. Ketamine works most effectively for people who have been struggling with depression for a long time and have not found success in any other treatment.

where can I find ketamine treatment?

Nue Life is an innovative new form of ketamine treatment. IV infusions of ketamine are expensive and time-consuming. That’s why we specialize in oral ketamine administration. You can take your treatment in the comfort of your own home.

At Nue Life, we want to create a program that is best for you. During your consultation, we’ll guide you through our different treatment plans during your consultation and perform an evaluation to better determine what dosage is right for you.

But we are more than just another faceless company that provides medicine and nothing else. Our community of KetaCounselors will guide you through your ketamine experiences, consulting you and giving you meaningful insights that can bring long-lasting, sustainable change to your depression by fighting it at its source.

This ketamine treatment is effective and holistic. It’s your right to feel good. And the research shows that ketamine could provide you the mental reset you may need to put your depression to bed.

conclusion

So now you know everything there is to know about ketamine and its effects on depression. Ketamine is not just another psychedelic drug. It’s an effective medical treatment that can give you immediate and meaningful relief from the illness that ails your mind.

So consider ketamine today. Your first consultation with Nue Life is completely free so that you can learn more about our therapies without any commitment.

If you need immediate improvement for your depression, if SSRIs just aren’t cutting it, if you have PTSD from your time in the service, or you’ve battled with depression your whole life, ketamine could be the solution you’re looking for. Nue Life programs are designed to help you find the mental reset you’ve been searching for.

by Rachel Buck

A Simple Practice to Build Clarity

It’s hard to have clarity about what you want from life when all the so-called answers are coming from the outside. Knowing your true path can only come from the inside. But if you don’t have a connection to your inner self, you are never going to get the clarity you want.

No one else can tell you what’s right for you. You can follow the prescribed paths of what is supposedly “right” but it doesn’t mean that it’s right for you. When you’ve followed prescribed paths for too long, you have severely limited your capacity to see what’s right for you, much less believe in your choices. It’s a natural outcome of suppressing your impulses in the service of achieving goals. Which is not a bad thing, unless that’s the only thing you can do.

Letting go of the “have to”

Being able to let go of your “have to” can be tough. Especially when your ability to achieve has built your confidence. But what happens when you’re not doing what you’re “supposed” to do? Does your confidence from seeking achievement transfer to your ability to choose for yourself? In other words, can you enjoy life without a task to complete?

Without following someone else’s prescribed path, you tend to lose interest. You’re looking for the next thing to achieve, but you’re not sure how that achievement will be useful in your life. 

Be your own authority

The only way to get clarity and experience your achievements as meaningful is to be your own authority. To do that, you must tune into your impulses and act on them.

That’s not to say you should be irresponsible. It means that you start a practice that allows you to fully notice and act upon your impulses.

This practice can be as simple as paying attention to your feelings when you make a choice about what food you want, or what clothing you feel like wearing. When you practice in simple ways like this, you build your capacity to notice the sensations in your body that motivate your choices. It is this capacity to notice your sensations that is the foundation of being your own authority. It is also the trick to having clarity about the bigger things in your life.

What having clarity looks like

When you are authentically motivated by your own impulses, you will have the clarity you are looking for. You will be able to make choices about what’s right for you, and you will know why you make those choices. The things you do will not be a mystery anymore.

Any resistance you get from others to conform to their standards will be easy to stand up to because you are confident in your own choices. Ridicule or humiliation used to try and sway your decisions will be weak against your confidence.

Clarity looks like a life where you enjoy what you’re doing because you know why you’re doing it and it has meaning for you. Your choices are in line with the overall goals you have for your life.

 

 

by Tatyannah George

A Secret For Better Sleep

If you have trouble falling asleep because of racing thoughts, you are not alone.

This problem is so common that there are literally hundreds of thousands of sources where you can find lists of ideas about how to calm yourself down before you go to bed.

These include breathing techniques, meditation apps, and even lifestyle adjustments such as exercising moderately, avoiding caffeine late in the day, eating carbs to stimulate serotonin and getting sunlight in the morning. The list can be seemingly endless.

Why you may have trouble falling asleep

When your thoughts won’t stop racing it’s because there are feelings in your body that have split off from your consciousness. For whatever reason, you don’t want to feel them. Your mind is working really hard to keep you from feeling them. But by doing that, it’s creating a problem than if you were to simply feel your feelings.

During the day, there are lots of ways you can distract yourself from the sensations of your body and avoid your feelings. But at night, these feelings inevitably resurface and cause you to have trouble falling asleep.

The secret

Generally, the feelings that make your thoughts race are fear and sadness, mostly generated due to a feeling of helplessness. If you can’t figure out which feeling it is, then the content of your worrisome thoughts will probably clue you in. Once you can recognize feelings associated with your racing thoughts, you can try to let them move through you.

In other words, the secret to getting rid of the racing thoughts is to feel the feelings associated with them. It’s really the only way. You will never get relief from a feeling that isn’t expressed. And even if you try to avoid it, it will always find its way to being expressed, either directly or indirectly. Hence, the racing thoughts.

What this means is that if you follow this advice, you will probably find yourself feeling more emotions than usual. If you follow this advice and can’t seem to get to your feelings, there is some other work you need to do to prepare yourself to feel them more easily.

When you breathe more, you feel more

To feel more easily, you must deepen and expand your breathing. There are many ways to deepen and expand your breathing, but one of my favorites is sitting for five minutes over a stability ball with your arms raised. Once you have started breathing at a steady rhythm you are much more likely to notice and have access to emotions in your body. Now you can try to feel the feelings associated with your racing thoughts.

Once you have expressed whatever feelings you have inside you, your body will naturally return to a state of equilibrium. The racing thoughts will be gone and you will relax, and if you are tired, you will have no trouble falling asleep.

by Tatyannah George

Intrusive Thoughts: Egosytonic vs Egodystonic

Intrusive Thoughts (ITs) intrude upon your ongoing thought processes and startle you with attention-grabbing content or imagery.

Intrusive thoughts are common - research says that 94% of the population experience them occasionally. 

Intrusive Thoughts can be categorized in two forms:

  • Egodystonic thoughts: which are an expression of wishes that oppose your values
  • Egosyntonic thoughts: which are an expression of wishes aligned with our values. 

It is best to understand what your intrusive thoughts say about you. These thoughts usually hone in on what is important to you. You will never have an intrusive thought about a topic your brain finds irrelevant, such as “oh no, what if my shoes get untied?” Your brain will only exert the effort to offer up an intrusive thought about something you care deeply about and its fears may be threatened. 

The flip side of your intrusive thought is what you value the most.

However, these thoughts DO NOT reflect your hidden desires. Experiencing an intrusive thought does not make you “deranged” or “depraved” because the only unhealthy thing about your experiences with intrusive thoughts is how hard you are trying to not have these thoughts. What you may find to be true is that there is a difference between a bad thought and a bad behavior. 

Thought Suppression Exercise

  1. Intentionally think about an intrusive thought. 
  2. For the next minute, place your attention on anything except for the intrusive thought. (find something a sense can attract to - the sound of birds outside, the ac unit running, the pen in front of you, the mint inside your mouth, etc)
  3. After 1 minute, note your anxiety levels on a 0-10 scale
  4. Next, for another minute, practice bringing forth the same intrusive thought. 
  5. After 1 minute, note your anxiety levels again on 0-10 scale. 

With this exercise, you can teach your brain to grow bored with your intrusive thoughts as we have realized in neuroscience that repeated attention to the intrusive thought will reduce reactivity over time (not so instantly) and can be done without necessarily seeking some answer to the reasons why they are rising within our thoughts. 

by Tatyannah George